Biologic disc treatments

[Crystal33]

Rob,
I have not had the fibrin procedure, but it is one of only a few minimal approach possibilities for me. There are a number of very happy patient outcomes posted about it on the net. As Mark mentioned, Dr. Kevin Pauza in TX is name mentioned. A phase III trial indicates they are serious about it.

Aaron, Mark
Beer in quantity would be effective pain management.
But wine is needed for disc regeneration.
The Action of Resveratrol, a Phytoestrogen Found in Grapes,... : Spine
And glucosamine to help heal tears.
The complete Homer spine care system.

[Aaron]

I am a skeptic but I am very interested in Dr. Pauza trials. But damn, the criteria and testing to make sure you are a good fit is crazy, if what I read about the trial is true. But I am excited as it says if the trial works he wants to expand to cervical and thoracic spine injections.

As spine patients I think I fall into the " I will try anything once " category when dealing with spine so I am trying to contact him concerning if he is going to do a thoracic trial for fibrin. Props for bringing this study to my attention crystal.

Yea Mark I started my own trials on the benefits of beer long ago. Have not yet found many, but I still trudge on ( for the good of man of course).

In all seriousness could you imagine if wine was discovered to work. Sales would hit the roof.

[Crystal33]

Aaron,
I do have a little more red wine than usual, to help the scientific research.
I suspect that a comprehensive and disciplined multi modality approach would be needed to slow/halt/reverse early disc degeneration. A disc without full thickness tears might also be needed, and a youngish age would also help.

This current trial is hoping to reverse early lumbar disc degeneration by a single injection.
Degenerative Disc Disease Clinical Trial: A Multicenter, Randomized, Double-blind, Placebo Controlled, Clinical Trial to Evaluate the Safety, Tolerability and Preliminary Effectiveness of Single Administration Intradiscal rhGDF-5 for the Treatment of

And this recent study claims non-surgical spinal decompression reduces back pain and increases disc height, which would be one ingredient to any regeneration. I think the decompression might work best before a person went to sleep so that it wasn't followed by loading up the disc again and maybe undoing any benefit.
BioMed Central | Full text | Restoration of disc height through non-invasive spinal decompression is associated with decreased discogenic low back pain: a retrospective cohort study

[Crystal33]

Maybe Mark or someone else may have researched this.....Nonsurgical EXogenous crosslink Therapy (NEXT)
It sounds almost too good to be true........."the treatment will be far less inexpensive than invasive surgeries as it only requires one outpatient procedure. It works immediately and offers more permanent pain relief".

Biotech company wins grant, continues innovative project

Our Technology

Optimization of Protein Crosslinking Formulations ... [Spine (Phila Pa 1976). 2010] - PubMed result

The Effects of Exogenous Crosslinking on Hydration... [Spine (Phila Pa 1976). 2010] - PubMed result

Exogenous crosslinking recovers the functional int... [J Biomed Mater Res A. 2010] - PubMed result